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Abstracts of published research articles in Ayurveda |
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Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar. |
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It is a popular perception prevailing throughout the globe that,
the traditional practices (let it be Ayurveda, Siddha or Unani)
doesn’t produce any adverse effects. The utilization of thesed
drugs since thousand of years itself supports this notion. But,
in present scenario, increased globalization of these practices
has raised concerns about their safey and efficacy, whichcreated
doubts on Indian heritage. To tackle these concerns, a system
like Pharmacovigilance is needed to be established. Considering
this, Dept. of AYUSH, Ministry of Health & Family Welfare, New
Delhi launched Pharmacovigilance Programme for ASU Drugs and
announced establishment of a National Pharmacovigilance Resource
Centre at IPGT &RA, Jamnagar which will look after drug related
incoveniences of traditional practices. The present article will
provide a brief out look of the programme since inception.
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| Key words:
Pharmacovigilance, Ayurveda, Siddha, Unani,
Regional Centres, Adverse effects, Peripheral centres. |
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| *
Lecturer, Dept. of Rasa Shastra & Bhaishajya Kalpana Email:
nprcasu@gmail.com **
Reader in Dravyaguna,
Member Secretary,
National Pharmacovigilance Resource Centre for ASU Drugs. |
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National Institute of Ayurveda and S.M.S.
Medical College & Hospital,
Jaipur - 302002 (Rajasthan)
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The study was conducted for the clinical
evaluation of ‘Menorid Capsules’ (A Proposed Herbomineral
formulation) in the management of Menopausal Syndrome
on various scientific parameters. Thirty clinically
diagnosed cases were
selected from O.P.D. / I.P.D. of the National
Institute of Ayurveda Hospital, Jaipur and S.M.S. Medical
College attached Hospital, Mahila Chikitsalaya, Jaipur. The
cases were randomly divided into three groups - Group I (Control
Group - Oral Conjugated equine estrogen), Group II (Trial group
- Menorid Capsules) and Group III (Placebo group - Capsules
filled with Starch). It was observed that overall clinical
improvement was maximum in patients of Group II. Overall
improvement in Laboratory parameters was maximum in patients of
Group I. Patients of Group III developed mild improvement in the
feeling of wellbeing. The
patients of Group I developed some adverse symptoms, but no
adverse effects were reported in any of the patients of the
Group II & III. From the current research project, it can be
concluded that the trial
drug ‘Menorid capsules’ is a safe, dependable and cost effective
remedy for the management of the patients of Menopausal
Syndrome. |
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| Key words:
Menorid Capsules, Menopausal Syndrome, Hormone Replacement
Therapy ( HRT). |
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*
Professor & Head, P.G. Dept. of Kayachikitsa
E-mail : ajay_sharma_54@hotmail.com
**
Associate Professor, Dept. of Obs. & Gynae., S.M.S. Medical
college & Hospital. ***
M.D. (Ay.) Scholar, P.G. Dept. of
Kayachikitsa |
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar. |
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Depression is the commonest psychiatric disorder affecting 121
million peoples worldwide. Vishada and Avasada are the two
conditions in Ayurveda , which are similar to depression.
Ayurveda is enriched with various ‘Medhya rasayana drugs’ in
which Brahmi ghrita is one herbal formulation. A randomized
placebo controlled clinical trial was carried out with the aim
to evaluate the anti depressant and psychoactive effect of
Brahmi ghrita on depression. Total 42 patients fulfilling the
DSM-IV criteria for major depressive episode were registered for
study. Out of 42, 35 patients completed the treatment. In these,
total 25 patients were managed with Brahmi ghrita and 17 with
placebo capsule. In the former group, 20 patients completed the
treatment, whereas in the later,15 patients completed treatment.
Specialized Ayurvedic rating scales like Manasa Pariksha Bhava,
Manasa Vibhrama Pariksha as well as Hamilton Depression Rating
Scale (H.D.R.S.) was adopted to assess the effect of therapy.
The effects were also examined on Chief complaints and
associated complaints of depression. When effect on H.D.R.S. was
analyzed, Brahmi ghrita showed moderate improvement in 50%
patients and mild improvement in 35% patients. Its total effect
was statistically highly significant (p<0.005) as compared to
placebo. Also, in overall effect, Brahmi ghrita resulted in
moderate improvement for 40% patients and mild improvement for
55% patients, which is statistically significant at 1% level as
compared to placebo. |
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| Key words:
Brahmi ghrita, Depression ,Manasa pariksha bhava, Manasa
vibhrama pariksha, Hamilton Depression rating scale |
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*
SRF - AYU and Ph.D. Scholar, Dept.
of
Panchakarma & Manasa Roga, E-mail:
dryogeshsd@yahoo.co.in
**
Professor of Kayachikitsa & Dean - I.P.G.T. & R.A..
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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Shinshapa (Dalbergia sissoo
Roxb.) belongs to family Fabaceae. Stem bark of Shinshapa is
mentioned in Gridhrasi (Sciatica) by Acharya Vangasena.
It suggests that Shinshapa may have analgesic
and anti inflammatory properties. No references available on
Pharmacological activity in the form of Ghanavati of
stem bark of Shinshapa. To provide experimental basis
to it, this study has taken up. Shinshapa (Dalbergia
sissoo Roxb.) Ghana vati (Dried water extract) as
test drug and Parijata (Nyctanthes arbortristis Linn.) Ghana
vati (Dried water extract) as reference standard drug were
assessed for analgesic and anti inflammatory effect on Wistar
strain albino rats and Swiss albino mice at a dose level of
200mg/kg po and 260 mg/kg po respectively. Dose fixation was
done according to Paget and Barnes (1969). Anti inflammatory
activity was evaluated by employing, Carageenan induced hind paw
oedema in albino rats and Formaldehyde induced hind paw oedema
in albino rats, while analgesic effect was evaluated by
employing, Formaldehyde induced paw licking in albino rats and
Tail Flick Response in mice. Result indicates presence of only
the moderate effect in reference standard- Parijata and
weak to moderate anti-inflammatory and moderate analgesic
activity in the test drug- Shinshapa. Thus it can be
suggested that this study failed to provide an un-equivocal
experimental evidence as basis for their clinical efficacy in
the treatment of Gridhrasi (Sciatica) |
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| Key words:
Shinshapa, Analgesic, Anti inflammatory, Pharmacology. |
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*
Lecturer in Dravyaguna, Govt. Ayurveda College, Junagadh, E-mail
: drrupani_rt@yahoo.com
**
Lecturer, Department of Dravyaguna ***Head
- Pharmaceutical Chemistry Laboratory ****Head
- Pharmacology Laboratory
*****
HOD - Dravyaguna
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Regional
Research Institute - Ayurveda, Tadikhet, Ranikhet, Uttarakhand
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Bio-science problem is very wide and deep. Mathematical
application in various bio-sciences problems is emphasized. The
simple and relative equations have been developed for the
determination of different constant values from iodine value. |
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| Key words:
Bio-science, Musaka taila, Equation, Iodine value. |
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*
Ex-Research Officer - Chemistry, 9, Ganesh colony, Naya Bazar,
Gwalior
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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Ayu is defined as
conjunction of body, mind, soul and senses. Each has been given
due importance in the maintenance of health and prevention and
cure of disease. Rheumatoid Arthritis (Amavata) is one of the
crippling diseases, claiming
maximum loss of human power. It is not only a disorder of
locomotor system, but
also is a systemic disease and named,
after its chief pathogenic constituents i.e. Ama and Vata
in Ayurveda. The main
causative factor, Ama is the result of malfunctioning of
digestive and metabolic mechanisms. The disease is initiated by
the consumption of diets prepared with some ingredients of
opposite qualities (Viruddha Ahara) and simultaneous indulgence
in Viruddha Ahara in the pre-existence of Mandagni. Though,
according to Ayurveda, Ama and Vata are chiefly pathogenic
factors, Kapha and Pitta are also invariably involved in its
pathogenesis. Primarily the pathogenesis (Samprapti) originates
in the gastro-intestinal tract (Annavaha
srotasa) then branches out through the Madhyama rogamarga,
the middle aspect of pathogenic process of disease, with special
inclination for Shleshma sthana especially articular joints (Sandhi).
Rasa, Asthi and Majja Dhatus are primarily involved. Dushyas
like Mamsa Dhatu, Snayu and Kandara are also affected.
Sandhishoola, Sandhishotha, Inhibition of joint movement (Stabdhata)
and intolerability on touch in joints (Sparshasahyata) are
salient feature of the disease. The disease Amavata has a
chronic course and malaise, anorexia, heaviness of the body
nausea, fever etc. are responsible for crippling of the patients
in the long run. In the present study, Matra Basti with
Prasarani Taila, Vatari
Guggulu are selected as the remedy of Amavata, due to properties
like Amanashana, Vatashamana, Deepana, Pachana and Rasayana
Prabhava.In the present study, 28 patients of Rheumatoid
Arthritis divided into
two groups were treated with Vatari Guggulu orally and along
with Prasarani Taila Matra Basti for 30 days. The effects of
therapy were assessed by a specially prepared clinical research
proforma. The result showed that better symptomatic relief was
observed in Matra Basti group in comparison to Vatari Guggulu
group. |
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| Key words:
Amavata, Rheumatoid arthritis, Matra Basti, Vatari Guggulu |
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*District
Co-ordination Officer of Ayurveda, Balurghat District Hospital,
Dakshin Dinajpur,
West Bengal,
E - mail:
asishdas06@yahoo.co.in **
Professor & H.O.D.- Kayachikitsa ***Professor
of Kayachikitsa &
Dean - I.P.G.T. & R.A.
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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The kidneys play a very important role in the maintenance of
homeostasis in the body. They perform several important
functions like normal fluid and acid base balance, electrolyte
balance, production and secretion of hormones and excretion of
metabolic products. Kidneys are highly vascularized organs
receiving around 20-25% of the cardiac output, because of this
reason they are constantly exposed to xenobiotics including
environmental pollutants, and hence are on the risk of
nephrotoxicity. In Ayurveda several drugs are used as
nephroprotectives, in this study the well known Ayurvedic
compound formulations ' Varunadi Ghrita' and 'Tiladi Kshara'
were used to evaluate the nephroprotective effect against
gentamycin induced nephrotoxicity. Total 36 animals in 6 groups
were taken and weighed. Test drugs and vehicles were
administered to respective groups, after two hours, Gentamycin
(60 mg./kg. I.P) was administered to all groups except water
control group for 15 consecutive days. On 16th day animals were
weighed again and sacrificed by cervical dislocation and
severing the jugular veins. Blood samples and kidneys were
collected for estimation of serum biochemical investigations and
histopathological studies respectively. Accurately weighed
kidney tissues were also taken and homogenate was prepared for
the estimation of different biochemical investigations.
The result in the context of the objective of the study
emerges that Varunadi Ghrita possess moderate nephroprotective
activity. However, the study could not provide basis for its
relevance to the probable efficacy of the test drug in kidney
stone induced nephropathy. |
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| Key words:
Nephroprotective activity, Kidney, Gentamycin, Varunadi Ghrita,
Tiladi Kshara. |
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*
R.M.O., Instt. of P. G. Ayurvedic Education & Research,
Shyamadas Vaidya Shastra Peeth, Kolkata
**
HOD - Basic Principles & Ex-I/c Director
***Reader
in Shalakya Tantra
****Head
- Pharmacology Laboratory
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Faculty of Ayurveda and Centre of
Experimental Medicine & Surgery, Institute of Medical Sciences,
Banaras Hindu University, Varanasi
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Kitibha is a type of kshudra kushtha described in different
Ayurvedic classics. It is a Vata-Kaphaja disorder.
The clinical symptoms of
Kitibha described in Ayurveda resembles with the clinical
symptoms of Psoriasis. The clinical features of Kitibha
described by Kashyapa represents remission, relapse and seasonal
variation, which is present in Psoriasis. It is one of the most
common dermatological problems of unknown etiology. It is a
chronic, genetically determined, inflammatory and proliferative
disease characterized by dry, well-circumscribed, silvery
scaling papules and plaques of various sizes with spontaneous
remission, relapse and seasonal variation. Lesions
distributed all over
the body with silvery scales, covering loops of dilated
superficial capillaries underneath which are presented as tiny
bleeding points on removal of scales (Auspitz’s sign). It
affects about 2% of world population. Various races and
communities differ in the susceptibility to this disease. In
India it affects about 1.5% of population including both the
genders. It appears to be common in Europeans than in Orientals.
Psoriasis like other skin disorder
is a challenge to the medical sciences. In modern
medicine there is no definite treatment for this disease. The
medicines which are available to treat the disease are not very
effective and can not be used for long term management because
of their local and systemic side effect as well as toxicity.
Medicines which are used in Ayurveda are safe and being
practiced since thousands of years. A large number of drugs are
described in Ayurveda for the treatment of kushtha. Keeping this
view in the mind,
Guduchi and Bakuchi were selected as oral drugs and a Taila for
local application which contains Tuvarak
taila, Chakramarda beej, Snuhi ksheer and Gomutra was
chosen. |
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| Key words:
Psoriasis, Kitibha,
Ayurveda, Guduchi, Bakuchi, Tuvaraka taila. |
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*
Ph. D. Scholar in Kayachikitsa, E- mail :
drpkraibhu@gmail.com
**
Sr. Lecturer in Kayachikitsa
*** Professor & HOD - Kayachikitsa
****Jr.
Research Officer, CEMS
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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Kushmanda is a well known plant since Vedic period. It is
botanically known as Benincasa hispida (Thunb.) Cong.
belonging to the family Cucurbitaceae. It has been highlighted
for its Medhya, Mutral, Vrishya etc. properties by various
Ayurvedic authors. Its seeds are used by some tribals for
enhancing sexual power. The seeds of Benincasa hispida
procured from Agra (U.P.) were authenticated in pharmacognosy
laboratory of I.P.G.T. &
R.A. to prepare granules in the pharmacy of Gujarat Ayurved
University. Total 30 patients
were randomly divided in two groups and treated with:
Placebo - wheat flour tablet, 2 tab. twice daily with 3
gms of sugar and lukewarm water and
Kushmanda seed granules, 6 gms twice daily with lukewarm
water for 45 days. The assessment was done on the basis of
changes in seminal parameters and sexual health parameters. The
study revealed that Kushmanda seed granules increased penile
erection, rigidity and orgasm etc. |
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| Key words:
Kushmanda beeja, Vrishya, Sexual parameters, Seminal parameters.
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*
Lecturer, Akhandanand Govt. Ayurveda College, Ahmedabad
**
Professor & HOD - Dravyaguna
***Reader
in Dravyaguna
****Head
- Pharmacology Laboratory
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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| Trachoma
is one of the diseases, having multiple follicles in the lids
resembling red mustard seeds, occurring mainly due to vitiation
of Kapha Dosha. Trachoma is a specific communicable
keratoconjunctivitis usually of chronic nature caused by the
Chlamydia trachomatis. It is primarily affecting the superficial
epithelium, characterized by formation of follicles, papillary
hyperplasia and pannus; the natural resolution of which is by
cicatrisation involving potentially considerable visual
disability. The study was done on 49 patients of Pothaki-Trachoma.
Pippalyadi eye drops were instilled in group A and Ofloxacin in
group B as a standard control. After enrollment of the patients
in the study, vital signs and symptoms of Pothaki-Trachoma such
as discharge, itching, heaviness, swelling etc. were studied
before and after the treatment. Amongst the registered patients
16 patients completed the course of treatment in group A and 15
patients in group B. In group
A, 43.75% patients got moderate improvement, 50.00% got
mild improvement and 6.25% were unchanged, whereas none of the
patients were completely cured. In group
B, 26.67% got
marked improvement, 53.33% were moderately improved and 20% got
mild improvement. |
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| Key words:
Pothaki, Trachoma, Pippalyadi eye drops. |
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*
Ph.D. Scholar, Dept. of
Shalakya Tantra
**
Reader, Dept. of Shalakya
***Honorary
Ophthalmologist, Jamnagar
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Institute of Medical Sciences, Banaras
Hindu University, Varanasi
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Depression is an important psychiatric disorder in medical
condition. This can interfere significantly an individual’s
ability to function. The difficult life situation and
unrealistic thinking are most important precipitating factors
for depressive disorder in majority of cases. These problems can
not be tackled completely through pharmacotherapy unless their
causes are rooted out completely by psychotherapeutic
intervention. Cognitive behaviour therapy (CBT) is an
established treatment for depressive illnesses. In the present
study a comparative evaluation of CBT has been done with the
Sattvavajaya, the Indian form of psychotherapy described in
ancient medical literature of Ayurveda. The intra group
comparisons based on the assessment of results on N-I scale, MHQ
and Adjustment scale have been presented, which demonstrate
comparable results. |
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| Key words:
Depression, Cognitive behaviour therapy, Sattvavajaya,
Santwana, Ashwasana, Driti, Smriti, Yoga nidra. |
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*
Research Scholar, Department of
Kayachikitsa
**
Reader, Department of
Kayachikitsa and Incharge, Division of Manas Chikitsa
E-mail:drijstripathi@rediffmail.com
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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Stroke is not a disease in itself but is heterogeneous group of
disorders. Hemiplegia is one of the most frequent clinical
presentations of stroke (CVA). Pakshaghata is clearly correlated
with hemiplegia according to signs and symptoms described in
various Ayurvedic literatures. Though ample research is being
carried out for alleviating the disease and new avenues are
being explored for treating early ischemic injury, yet the
disease still remains incurable. In this study the line of
treatment for Pakshaghata
i.e. Virechana Karma as mentioned by Charaka has been
studied. Basti Karma, the first line of treatment for Vata
Vyadhi like Pakshaghata was selected
for the study. After the completion of
the study, comparative admirable results were observed by
Basti Karma in contrast to Virechana Karma. |
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| Key words:
Virechana Karma, Kala Basti, Pakshaghata, Hemiplegia, CVA.
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*
M. D. (Ayu.), Department of Panchakarma
**
Head - Department of Panchakarma ***Panchakarma
Assistant, Department of Panchakarma
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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Kikkisa is Tridoshaja Vyadhi clinically
characterized by burning, itching, stretch marks on the body
particularly on the abdomen, thighs and breast region. It is
usually found in the second trimester of pregnancy particularly
in the seventh month due to the overstretching. It can be
correlated with Striae gravidarum from modern science. It is the
major problem of modern cosmetic conscious era, where more than
90% of the women suffer from this condition. It makes much
psychological distress to the women.
Considering the above facts, for the present study 64
patients were selected for clinical study, out of which 57
patients completed the course of treatment and were randomly
divided into three groups. Each group was further divided into
two sub-groups i.e. preventive and curative. In group A, 10 gm
of Savarnakara Ghrita was given twice a day for oral
administration for two months. In group B, Savarnakara cream in
sufficient quantity was given for local application twice a day
for two months. In group C, wheat flour capsule (500 mg) was
given twice with Krishna Mruttika Lepa twice a day for two
months.
Better therapeutic response had been
observed in Group B than Group A. In Group C, the condition of
most of the patients started deteriorating. It was found that
therapy is more effective in preventive group than in curative
group. |
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Key words:
Kikkisa, Striae gravidarum, Savarnakara Ghrita, Savarnakara
Cream. |
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*
Lecturer,
Dept. of Stri Roga & Prasuti Tantra, Akhandananda
Govt. Ayurveda College, Ahmedabad
**
Lecturer, Dept. of Stri
Roga & Prasuti Tantra
***Professor
& Head, Dept. of Stri Roga & Prasuti Tantra
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| Institute for Post Graduate
Teaching and Research in Ayurveda, Gujarat Ayurved University,
Jamnagar |
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Pratishyaya is a
complex disease involving several symptomatologies and
diverse pathogenesis. It is well known for its recurrence and
chronicity. Recurrence of the disease occurs because the Doshas
reside in their latent stage (predisposing stage) & give rise to
the same disease when aggravating factors are favourable.
The specific features of a child like Dosha Dushya
Malalpata, Saukumaryata, Aparipakwa Dhatu, Asampurna Bala etc.
lower the immune status of the child & makes him/her more
susceptible for repeated infections like Pratishyaya. Recurrent
Upper Respiratory Tract Infections (RURTI) are can be corelated
with Pratishyaya. URTIs
include colds and influenza-like illnesses having
significant impact on the health and academic performance
of students.The textbook of modern medicine clearly states that
there is no proper standardized treatment for URTIs & has lots
of limitations. Injudiciously
use of antibiotics & steroid to infants and young
children leads to depression of immune system. Therefore,
patients are continuously looking with a hope towards
Ayurveda to overcome this challenge.
In the present study, total 40 patients were registered
and randomly divided into two groups. In group A, Mustakadi
Avaleha & in group B, Gojihwadi Avaleha was given for
6 weeks.The Nidana, signs & symptoms were observed
carefully to get idea about the Samprapti of the disease. The
effects of therapy in both groups were assessed by a specially
prepared proforma. The result obtained showed striking
similarity. In both the
groups, an apparent difference in all the sign & symptoms was
observed. In Mustakadi Avaleha and Gojihwadi
Avaleha group maximum number of patients i.e. 53.33% and 46.67%
of patients respectively showed marked improvement. |
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| Key words:
Pratishyaya, Recurrent Upper Respiratory Tract Infections,
Mustakadi Avaleha, Gojihwadi Avaleha. |
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*
Lecturer in Kaumarabhritya, Chaudhari Devilal College of
Ayurveda, Jagadhari, Dist. Yamuna Nagar, Haryana
**
Hon. Pediatrician
***Reader
& H.O.D. - Kaumarabhritya
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